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《医学前沿(英文)》 doi: 10.1007/s11684-023-1043-5
关键词: coronavirus disease 2019 SARS-CoV-2 epidemiology clinical features
Coronavirus disease 2019 (COVID-19): a clinical update
Min Zhou, Xinxin Zhang, Jieming Qu
《医学前沿(英文)》 2020年 第14卷 第2期 页码 126-135 doi: 10.1007/s11684-020-0767-8
关键词: coronavirus disease 2019 epidemiology pathology radiology clinical characteristics treatment
Translating evidence into policy in China: opportunities and challenges
Jiyao Wang, Xuejuan Jin
《医学前沿(英文)》 2011年 第5卷 第3期 页码 315-320 doi: 10.1007/s11684-011-0146-6
关键词: clinical epidemiology evidence-based decision making policy
《医学前沿(英文)》 2023年 第17卷 第3期 页码 518-526 doi: 10.1007/s11684-022-0958-6
关键词: acute lymphoblastic leukemia child venous thromboembolism epidemiology clinical characteristic risk factor
null
《医学前沿(英文)》 2018年 第12卷 第1期 页码 76-83 doi: 10.1007/s11684-017-0609-5
Tuberculosis (TB) has remained an ongoing concern in China. The national scale-up of the Directly Observed Treatment, Short Course (DOTS) program has accelerated the fight against TB in China. Nevertheless, many challenges still remain, including the spread of drug-resistant strains, high disease burden in rural areas, and enormous rural-to-urban migrations. Whether incident active TB represents recent transmission or endogenous reactivation has helped to prioritize the strategies for TB control. Evidence from molecular epidemiology studies has delineated the recent transmission of ( ) strains in many settings. However, the transmission patterns of TB in most areas of China are still not clear. Studies carried out to date could not capture the real burden of recent transmission of the disease in China because of the retrospective study design, incomplete sampling, and use of low-resolution genotyping methods. We reviewed the implementations of molecular epidemiology of TB in China, the estimated disease burden due to recent transmission of strains, the primary transmission of drug-resistant TB, and the evaluation of a feasible genotyping method of strains in circulation.
关键词: tuberculosis recent transmission molecular epidemiology China
Chronic hepatitis B virus infection: epidemiology, prevention, and treatment in China
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 135-144 doi: 10.1007/s11684-014-0331-5
Chronic hepatitis B is a major health problem in China. The universal vaccination program since 1992 has changed the epidemiology of hepatitis B virus infection in China from highly to moderately endemic. The most prevalent hepatitis B virus strains in China are genotypes B and C, whereas those in western provinces are genotypes D and C/D hybrid. Chronic hepatitis B poses a heavy burden to the society in China. Different treatment strategies have been explored to improve patient outcomes in a cost-effective manner. However, antiviral drugs with a low genetic barrier to resistance are still extensively used because of the generally low income and limited resources in China. Individualized antiviral therapy is closely associated with translational medicine, which utilizes information from studies on genomics, immune biomarkers, and fibrosis. The results of these studies are crucial in further improving treatment outcomes.
The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes
Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang
《医学前沿(英文)》 2020年 第14卷 第1期 页码 1-7 doi: 10.1007/s11684-019-0733-5
关键词: molecular epidemiology norovirus disease burden genotype China
《医学前沿(英文)》 doi: 10.1007/s11684-023-1050-6
关键词: pancreatic cancer cancer screening single cell molecular alterations precancerous lesion therapy resistance
2018—2019年我国北方地区奶牛临床型乳房炎源肺炎克雷伯菌的分子特征 Article
宋士凯, 何文娟, 杨大伟, Manar Benmouffok, 王瑶, 李基云, 孙城涛, 宋祥彬, 马士珍, 蔡畅, 丁双阳, 吴聪明, 沈张奇, 汪洋
《工程(英文)》 2022年 第10卷 第3期 页码 146-154 doi: 10.1016/j.eng.2021.01.015
肺炎克雷伯菌是奶牛乳房炎的重要诱因,常引起奶牛的产奶量降低和死亡率增高。目前尚缺乏奶牛乳房炎源肺炎克雷伯菌分子特征的研究数据,限制了对其在食品生产链中传播风险的评估。本研究于2018—2019 年从我国北方地区患临床型乳房炎奶牛中采集了6301 份奶样,共分离到183 株肺炎克雷伯菌,两年的平均分离率分别为3.03%和2.80%。与人类临床肺炎克雷伯菌分离株相似,奶牛临床型乳房炎源肺炎克雷伯菌分离株可分为肺炎克雷伯菌(KpI,143 株)、准肺炎克雷伯菌(KpII-B,37 株)和变栖肺炎克雷伯菌(KpIII,3 株)三个种群。在KpI 分离株中检测到超广谱β-内酰胺酶(ESBL)的编码基因blaSHV-2a、blaCTX-M-14和blaCTX-M-15,以及可能与奶牛致病性和宿主适应性有关的编码基因clpC、lpfA、lacI、lacZ、lacY和fecABDEIR。KpI 菌株比KpII-B 和KpIII 菌株表现出更高的流行率以及抗生素耐药基因和毒力基因携带率,表明它可能对奶牛的危害更大。此外,还发现奶牛KpI菌株与人医临床分离的KpI菌株在种群结构上存在明显差异,且奶牛源KpI菌株中很少见到与人类侵袭性感染相关的基因,表明奶牛源KpI菌株对人类健康的威胁较小;奶牛KpII-B 分离株与人类感染分离株具有较高的核苷酸序列一致性,且它们携带固氮基因nif的比例都很高,表明奶牛和人类KpII-B 分离株与植物源性KpII-B 菌株之间存在一定关联。
Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic
William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu
《医学前沿(英文)》 2021年 第15卷 第4期 页码 507-527 doi: 10.1007/s11684-020-0814-5
关键词: H7N9 HPAIV epidemiology clinical features pathogenesis hemagglutinin immunity vaccine
Epidemiology of fungal infections in China
null
《医学前沿(英文)》 2018年 第12卷 第1期 页码 58-75 doi: 10.1007/s11684-017-0601-0
With the increasing number of immunocompromised hosts, the epidemiological characteristics of fungal infections have undergone enormous changes worldwide, including in China. In this paper, we reviewed the existing data on mycosis across China to summarize available epidemiological profiles. We found that the general incidence of superficial fungal infections in China has been stable, but the incidence of tinea capitis has decreased and the transmission route has changed. By contrast, the overall incidence of invasive fungal infections has continued to rise. The occurrence of candidemia caused by species other than and including some uncommon species has increased recently in China. Infections caused by have also propagated in recent years, particularly with the emergence of azole-resistant . An increasing trend of cryptococcosis has been noted in China, with var. ST 5 genotype isolates as the predominant pathogen. Retrospective studies have suggested that the epidemiological characteristics of pneumonia in China may be similar to those in other developing countries. Endemic fungal infections, such as sporotrichosis in Northeastern China, must arouse research, diagnostic, and treatment vigilance. Currently, the epidemiological data on mycosis in China are variable and fragmentary. Thus, a nationwide epidemiological research on fungal infections in China is an important need for improving the country’s health.
关键词: fungi infection epidemiology China
Ontological reconstruction of the clinical terminology of traditional Chinese medicine
null
《医学前沿(英文)》 2014年 第8卷 第3期 页码 358-361 doi: 10.1007/s11684-014-0348-9
This study proposes the ontological reconstruction of the current clinical terminology of traditional Chinese medicine (TCM). It also provides an overview of preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinical terminology. We conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation from the idealized organizational model to real-world implementation and to a formalized, shared, and knowledge-based framework.
关键词: ontology traditional Chinese medicine clinical terminology
2008—2017年河南省腹泻患者来源单相鼠伤寒沙门菌ST34的基因组流行病学特征研究 Article
穆玉娇, 李瑞超, 杜鹏程, 张沛, 李岩, 崔生辉, Séamus Fanning, 白莉
《工程(英文)》 2022年 第15卷 第8期 页码 34-44 doi: 10.1016/j.eng.2022.05.006
单相鼠伤寒沙门菌(Salmonella enterica serovar 4,[5],12:i:-, S. 4,[5],12:i:-)作为鼠伤寒沙门菌的变种,已成为全球公共卫生领域备受关注的新兴血清型,其在中国的基因组流行病学特征尚不明确。本研究对2008-2017年分离自腹泻患者的100株序列型34型(ST34)S. 4,[5],12:i:-开展的流行情况、耐药表型和群体基因组学的分析发现:多数菌株对氨苄西林、链霉素、磺胺类和四环素耐药(耐药表型ASSuT);基于贝叶斯系统发育分析,中国分离株起源于欧洲谱系,进化为携带不同耐药基因和质粒的两个分支。进化支1中gyrA基因点突变和质粒介导喹诺酮耐药基因携带率较高,而进化支2中多数菌株fljBA操纵子插入了耐药编码区域[编码ASSuT耐药表型,包括blaTEM-1B(氨苄西林耐药)、strAB(链霉素耐药)、sul2(磺胺类耐药)和tet(B)(四环素耐药)],导致了血清型单相变异。IncHI2质粒是该血清型中导致细菌严重耐药的主要可移动遗传元件,普遍存在于进化支1的分离株中。综上,多重耐药S. 4,[5],12:i:-菌株在中国的流行情况日益严重,且进化为携带不同耐药基因的多个谱系,需采取有效措施控制此人畜共患病原体的传播,并基于“同一健康”策略开展监测及制定干预策略。
Epidemiology, pathogenesis, and management of coronavirus disease 2019-associated stroke
《医学前沿(英文)》 doi: 10.1007/s11684-023-1041-7
关键词: SARS-CoV-2 ischemic stroke stroke hemorrhagic stroke cerebral venous thrombosis vaccination
《医学前沿(英文)》 2023年 第17卷 第3期 页码 527-533 doi: 10.1007/s11684-022-0967-5
关键词: orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation
标题 作者 时间 类型 操作
Pathogen evolution, prevention/control strategy and clinical features of COVID-19: experiences from China
期刊论文
Translating evidence into policy in China: opportunities and challenges
Jiyao Wang, Xuejuan Jin
期刊论文
Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese Children’s Cancer Group-ALL-2015
期刊论文
Recent transmission of Mycobacterium tuberculosis in China: the implication of molecular epidemiology
null
期刊论文
The epidemiology of norovirus gastroenteritis in China: disease burden and distribution of genotypes
Honglu Zhou, Songmei Wang, Lorenz von Seidlein, Xuanyi Wang
期刊论文
Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic
期刊论文
2018—2019年我国北方地区奶牛临床型乳房炎源肺炎克雷伯菌的分子特征
宋士凯, 何文娟, 杨大伟, Manar Benmouffok, 王瑶, 李基云, 孙城涛, 宋祥彬, 马士珍, 蔡畅, 丁双阳, 吴聪明, 沈张奇, 汪洋
期刊论文
Avian influenza A: an avian influenza virus from low pathogenic to highly pathogenic
William J. Liu, Haixia Xiao, Lianpan Dai, Di Liu, Jianjun Chen, Xiaopeng Qi, Yuhai Bi, Yi Shi, George F. Gao, Yingxia Liu
期刊论文